This policy brief focuses on digitalizing Micro, Small, and Medium Enterprises (MSMEs) in Indonesia. It explores how MSMEs can contribute to SDGs while ensuring decent work opportunities. In Indonesia, where MSMEs contribute significantly – 61% to the GDP and 97% to employment – this brief underscores their indispensable role as economic pillars. This policy brief delves into crucial aspects of MSMEs’ digital transformation, including digitalization, e-commerce, cybersecurity, and the digital divide. Specifically, it explores the challenges and opportunities presented by these areas and proposes recommendations to enhance digital capabilities. The brief introduces the MSMEs digitalization framework as a strategic roadmap, offering lessons for other countries. The recommendations aim to inspire collaborative efforts among G20 nations to support global MSMEs digitalization, fostering economic growth, reducing inequalities, and advancing sustainable development.